amelogenesis imperfecta (ai) is a disorder of tooth development where there is an abnormal formation of enamel or the external layer of teeth. the aim of this study was to screen mutations in the four most important candidate genes, enam, klk4, mmp20 and fam83h responsible for amelogenesis imperfect.geneomic dna was isolated from five iranian families with 22 members affected with enamel malfor...

background and objective: haemophilus influenzae type b (hib) is divided into two distinct genotypes, type i and type ii, based on the structure of capsular polysaccharides. the capsulation locus of haemophilus influenzae type b consists of three functionally distinct regions, designated regions 1 to 3. region iii contains hcsa and hcsb genes; however, notable sequence variation in this region ...

background : triple-negative breast cancers (tnbc) are defined as breast cancers with lack of estrogen and progesterone receptors and no overexpression of human epidermal growth factor receptor 2 (her2). this study was performed to determine the frequency and pathologic features of tnbc in iranian patients. subjects and methods: this cross-sectional study was performed on patients with breast c...

type 1 diabetes mellitus is frequently associated with autoimmune thyroid disease (atd).genetic susceptibility for autoantibody formation in association with atd and type 1 diabetes mellitus has been described with varying frequencies, but there is still debate about its prevailing situation in iran.  we have therefore investigated the prevalence of anti-thyroid peroxidase (anti-tpo) and anti t...

background: there is no documented demographical study on iranian parkinson's disease (pd) patients, so this study was conducted to identify demographic information about patients with pd in iran, and to explore demographical differences between pd patients in iran and other countries. methods: we reviewed medical records of 1656 patients diagnosed with pd, who referred from all parts of iran t...

Hemodialysis (HD) patients are recognized as one of the high-risk groups for hepatitis C virus (HCV) infection. The prevalence of HCV infection varies widely between 5.5% and 24% among different Iranian populations. Preventive programs for reducing HCV infection prevalence in these patients require accurate information. In the present study, we estimated HCV infection prevalence in Iranian HD p...

The geographical variation in Helicobacter pylori genotypes is an observed phenomenon. Cytotoxin associated genes A (cagA) and E (cagE), and vacuolating cytotoxin (vacA) genotypes of H. pylori are associated with peptic ulcer disease (PUD). This study compared the distribution of these genotypes in Iranian and Afghani isolates and their association with clinical outcomes. H. pylori infected pat...

A Pseudomonas aeruginosa strain (UCBPP-PA14) is infectious both in an Arabidopsis thaliana leaf infiltration model and in a mouse full-thickness skin burn model. UCBPP-PA14 exhibits ecotype specificity for Arabidopsis, causing a range of symptoms from none to severe in four different ecotypes. In the mouse model, UCBPP-PA14 is as lethal as other well-studied P. aeruginosa strains. Mutations in ...

Multidrug resistance (MDR) is a main cause of failure in the chemotherapeutic treatment of malignant disorders. One of the well-known genes responsible for drug resistance encodes the multidrug resistance- associated protein (MRP1). The association of MRP1 with clinical drug resistance has not systematically been investigated in Iranian pediatric leukemia patients. We therefore applied real-tim...